Welcome!

Moving South! - Streeck Lab joins the effort at MHRP
just published- 27th August 2012 - Tfh cells in HIV infection
Streeck Lab at AIDS vaccine 2012
HIV-specific CD4 T cell responses mediate early control of HIV replication
Comprehensive analysis of HIV-specific CD4 T cell responses - now published in JVI
Recent publications - Check out the Streeck lab publications from the last year
CROI 2012: Madelene Lindqvist will give a talk on HIV-specific TFH cells and Srinika Ranasinghe will present on discordant HLA-class II restriction of HIV-specific CD4 T cell responses -see you in Seattle 2012!
Lab Outing 2011 - The lab traveled to Randolph, MA for a day of paintball and fun...click for more photos.

Welcome to the Streeck Laboratory!

We study CD4 T cell responses and the role they play during HIV-infection, with an eye towards how these responses may be manipulated for an HIV vaccine.
HIV-1 preferentially infects CD4+ T helper cells, which play a crucial role in the orchestration of the immune system. The main function of CD4+ T helper cells is to direct and focus immune responses to maximize anti-pathogenic processes, while suppressing non-essential immune responses. In particular, the efficiency of CD4+ T cell help has been strongly associated with the efficacy of virus-specific CD8+ T cell function. Understanding exactly how CD4+ T helper cells coordinate the immune system and respond to immune challenges are likely crucial to the development of an effective HIV vaccine.

New studies from our laboratory demonstrate that HIV-1-specific CD4+ T helper responses are able to critically improve HIV-1-specific CD8+ T cells in their functionality but also to successfully inhibit viral replication. For more information, please see our Research and Publications pages.

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